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PublicationsLucid's VivaScopes® have been used by medical researchers around the world to pioneer imaging applications in dermatology and numerous other medical fields. An extensive list of publications related to Lucid's reflectance confocal microscopy technology is provided here. Copyright restrictions prohibit us from providing these publications in downloadable format. Reprints of many of these publications are available from the publisher and selected publications from the following list are available from Lucid, and can be requested on-line at this site.
Published and Presented WorksNote: All entries listed are from refereed medical or scientific journals unless denoted by italic type and the reference is followed by the notation (NR). Most of the work has been performed using either confocal microscopes manufactured by Lucid, or the underlying technology that led to the development of Lucid's microscopes. Non-refereed entries shown in italic type and denoted by (NR) include presented papers, poster papers, trade journal articles and other materials, and may include materials produced either in-part or entirely by Lucid, Inc. THE PUBLICATIONS PRESENTED HERE REPRESENT THE RESEARCH, VIEWS AND OPINIONS OF THEIR RESPECTIVE AUTHORS. THE PAPERS LISTED BELOW ARE PRESENTED AS A SERVICE TO OUR CUSTOMERS AND VISITORS TO THIS WEB SITE. LISTING OF A PUBLICATION DOES NOT INDICATE THE APPROVAL, ENDORSEMENT, OR RECOMMENDATION OF ANY OF THE RESEARCH RESULTS BY LUCID, INC. PUBLICATION RESULTS SHOULD NOT BE CONSIDERED OR CONSTRUED TO BE AN INDICATION FOR USE MADE BY THE COMPANY. Review PapersMeyer LE, Otberg N, Sterry W, Lademann J. "In Vivo Confocal Scanning Laser Microscopy: Comparison of the Reflectance and Fluorescence Mode by Imaging Human Skin". J Biomed Opt. Jul-Aug 2006; 11(4):044012. Tian KB, Zhou GY. "Advances of In-Vivo Confocal Scanning Laser Microscopy". Shanghai Kou Qiang Yi Xue. Feb 2006; 15(1):97-100. Chinese. Agero ALC, Benvenuto-Andrade C, Astner S, Patel Y, Rajadhyaksha M, González S. "Confocal Microscopy of Skin Tumors". Journal of Plastic Dermatology. 2005; 1:2. Ruocco E, Argenziano G, Pellacani G, Seidenari S. "Noninvasive Imaging of Skin Tumors". Dermatol Surg. Feb 2004; 30(2 Pt 2):301-10. Gonzalez S, Gilaberte-Calzada Y, Gonzalez-Rodriguez A, Torres A, Mihm MC Jr. "In Vivo Reflectance-Mode Confocal Scanning Laser Microscopy in Dermatology". Adv Dermatol. 2004; 20:371-87. Abramovtis W, Stevenson LC. "Changing Paradigms in Dermatology: New Ways to Examine the Skin Using Noninvasive Imaging Methods". Clin Dermatol. Sep-Oct 2003; 21(5):353-8. González S, Swindells K, Rajadhyaksha M, Torres A. "Changing Paradigms in Dermatology: Confocal Microscopy in Clinical and Surgical Dermatology". Clin Dermatol. Sep-Oct 2003; 21(5): 359-69. Aspres N, Egerton IB, Lim AC, Shumack SP. "Imaging the Skin". Australas J Dermatol. Feb 2003; 44(1):19-27. Kollias N, Stamatas N. "Optical non-invasive Approaches to Diagnosis of Skin Diseases". J Invest Dermatol Symp Proc. Dec 2002; 7(1):64-75. Selkin B, Rajadhyaksha M, González S, Langley RG. "In Vivo Confocal Microscopy in Dermatology". Dermatol Clin. Apr 2001; 19(2):369-77, ix-x. Rubinstein G, White WM, Rajadhyaksha M, González S. "Real Time In Vivo Confocal Microscopy: A Powerful Imaging Tool in Dermatology". Dermatología & Cosmética. Dec 1997; 274-277. Skin Cancer - Melanoma ResearchOno I, Sakemoto A, Ogino J, Kamiya T, Yamashita T, Jimbow K. "The Real-Time, Three- Dimensional Analyses of Benign and Malignant Skin Tumors by Confocal Laser Scanning Microscopy". J Dermatol Sci. Aug 2006; 43(2):135-41. Pellacani G, Guitera P, Longo C, Avramidis M, Sedenari S, Menzies S. “The Impact of In Vivo Reflectance Confocal Microscopy for the Diagnostic Accuracy of Melanoma and Equivocal Melanocytic Lesions”. J Invest Dermatol. Jul 2007; doi:10.1038/sj.jid.5700993. Gerger A, Koller S, Weger W, Richtig E, Kerl H, Samonigg H, Krippl P, Smolle J. "Sensitivity and Specificity of Confocal Laser-Scanning Microscopy for In Vivo Diagnosis of Malignant Skin Tumors". Cancer. Jul 1, 2006; 107(1):193-200. Langley RG, Burton E, Walsh N, Propperova I, Murray SJ. "In Vivo Confocal Scanning Laser Microscopy of Benign Lentigines: Comparison to Conventional Histology and In Vivo Characteristics of Lentigo Maligna". J Am Acad Dermatol. Jul 2006; 55(1):88-97. Pellacani G, Cesinaro A.M., Seidenari S. "Reflectance-Mode Confocal Microscopy of Pigmented Skin Lesions - Improvement in Melanoma Diagnostic Specificity". J Am Acad Dermatol. Dec 2005; 53(6):979-85. Pellacani G, Cesinaro A M, Seidenari S. "In Vivo Assessment of Melanocytic Nests in Nevi and Melanomas by Reflectance Confocal Microscopy". Mod Pathol. April 2005; 18(4):469-74. Chen C-S J, Elias M, Busam KJ, Rajadhyaksha M, Marghoob AA. "Multimodal In Vivo Optical Imaging, Including Confocal Microscopy, Facilitates Presurgical Margin Mapping for Clinically Complex Lentigo Maligna Melanoma". B Jr Dermatol. Nov 2005; 153(5):1031-6. Marghoob AA, Charles CA, Busam KJ, Rajadhyaksha M, Lee G, Clark-Loeser L, Halpern AC. "In Vivo Confocal Scanning Laser Microscopy of a Series of Congenital Melanocytic Nevi Suggestive of Having Developed Malignant Melanoma". Arch Dermatol. Nov 2005; 141(11):1401-12. Busam KJ, Marghoob AA, Halpern A. "Melanoma Diagnosis by Confocal Microscopy: Promise and Pitfalls". J Invest Dermatol. Sep 2005; 125(3):vii-ix. Pellacani G, Cesinaro AM, Seidenari S. "Reflectance-Mode Confocal Microscopy for the In-Vivo Characterization of Pagetoid Melanocytosis in Melanomas and Nevi". J Invest Dermatol. Sep 2005; 125(3):532-7. Paller AS. "Beyond Routine Visualization: PCR and In Vivo Confocal Microscopy for Melanoma Detection". J Invest Dermatol. Mar 2005; 124(3):vi-vii. Halpern AC, Rajadhyaksha M, Toledo-Crow R. "Bringing Histology to the Bedside". J Invest Dermatol. Mar 2005; 124(3):viii-x. Gerger A, Koller S, Kern T, Massone C, Steiger K, Richtig E, Kerl H, Smolle J. "Diagnostic Applicability of In Vivo Confocal Scanning Laser Microscopy in Melanocytic Skin Tumors". J Invest Dermatol. Mar 2005; 124(3):493-8. Pellacani G, Cesinaro A M, Seidenari S. "In Vivo Confocal Reflectance Microscopy for the Characterization of Melanocytic Nests and Correlation with Dermoscopy and Histology". Br J Dermatol. Feb 2005; 152(2)384-6. Pellacani G, Cesinaro AM, Longo C, Grana C, Seidenari S. "Microscopic In Vivo Description of Cellular Architecture of Dermoscopic Pigment Network in Nevi and Melanomas". Arch Dermatol. Feb 2005; 141(2):147-154. Curiel-Lewandrowski C, Williams CM, Swindells KJ, Tahan SR, Aster S, Frankenthaler RA, González S. "Use of In Vivo Confocal Microscopy in Malignant Melanoma: an Aid in Diagnosis and Assessment of Surgical and Nonsurgical Therapeutic Approaches". Arch Dermatol. Sep 2004; 140(9):1127-32. Pellacani G, Cesinaro AM, Grana C, Seidenari S. "In Vivo Confocal Scanning Laser Microscopy of Pigmented Spitz Nevi: Comparison of In Vivo Confocal Images with Dermoscopy and Routine Histopathology". J Am Acad Dermatol. Sep 2004; 51(3):371-6. McNamara D. "Confocal Image Peers Inside Melanoma". Skin & Allergy News. Feb 2004; 35(2):15. (NR) Marghoob AA, Swindle LD, Sanchez Negron FA, Slue B, Halpern AC, Kopf AW. "Instruments and New Technologies for the In Vivo Diagnosis of Melanoma". J Am Acad Dermatol. Nov 2003; 49(5):777-97. Swindle LD, Hazen CK, Feit NE, Busam KJ, Halpern AC. "Features of Melanocytic Lesions as Demonstrated on Reflectance and Fluorescence Imaging". Poster Presentation; Annual Meeting of the American Academy of Dermatology. Mar 2003. (NR) Charles CA, Marghoob AA, Busam KJ, Clark-Loeser L, Halpern AC. "Melanoma or Pigmented Basal Cell Carcinoma: a Clinical-Pathologic Correlation with Dermoscopy, In Vivo Confocal Scanning Laser Microscopy, and Routine Histology". Skin Res Technol. Nov 2002; 8(4):282-7. Busam KJ, Charles C, Lohmann CM, Marghoob A, Goldgeier M, Halpern AC. "Detection of Intraepidermal Malignant Melanoma In Vivo by Confocal Scanning Laser Microscopy". Melanoma Res. Aug 2002; 12(4):349-55. Tannous Z, Mihm M, Flotte T, González S. "In Vivo Examination of Lentigo Maligna, In Situ Malignant Melanoma, Lentigo Maligna Type by Near-Infrared Confocal Microscopy: Comparison of Confocal Images with Histologic Sections". J Am Acad Dermatol. Feb 2002; 46(2):260-63. Busam KJ, Charles C, Lee G, Halpern AC. "Morphologic Features of Melanocytes, Pigmented Keratinocytes, and Melanophages by In Vivo Confocal Scanning Laser Microscopy". Mod Pathol. Sep 2001; 14(9):862-68. Langley R, Rajadhyaksha M, Dwyer P, Sober A, Flotte T, Anderson RR. "Confocal Scanning Laser Microscopy of Benign and Malignant Melanocytic Skin Lesions In Vivo". J Am Acad Dermatol. Sept 2001; 45(3):365-76. Busam KJ, Hester K, Charles C, Sachs D, Antonescu C, González S, Halpern AC. " Detection of Clinically Amelanotic Malignant Melanoma and Assessment of Its Margins by In Vivo Confocal Scanning Laser Microscopy (CSLM)". Arch Dermatol. Jul 2001; 137(7):923-9. Non-Melanoma Skin Cancer ResearchBasal Cell CarcinomaSegura S, Puig S, Carrera C, Palou J, Malvehy J. "Dendritic Cells in Pigmented Basal Cell Carcinoma: A Relevant Finding by Reflectance-Mode Confocal Microscopy ". Arch Dermatol. 2007; 143(7):883-886. Agero AL, Busam KJ, Benvenuto-Andrade C, Scope A, Gill M, Marghoob AA, Gonzalez S, Halpern AC. "Reflectance Confocal Microscopy of Pigmented Basal Cell Carcinoma". J Am Acad Dermatol. Apr 2006; 54(4):638-43. Gerger A, Horn M, Koller S, Weger W, Massone C, Leinweber B, Kerl H, Smolle J. "Confocal Examination of Untreated Fresh Specimens From Basal Cell Carcinoma". Arch Dermatol. Oct 2005; 141(10):1269-74. Marra DE, Torres A, Schanbacher CF, Gonzalez S. "Detection of Residual Basal Cell Carcinoma by In Vivo Confocal Microscopy". Dermatol Surg. May 2005; 31(5):538-41. Nori S, Rius-Díaz F, Cuevas J, Goldgeier M, Jaen P, Torres A, González S. "Sensitivity and Specificity of Reflectance-Mode Confocal Microscopy for In Vivo Diagnosis of Basal Cell Carcinoma: a Multicenter Study". J Am Acad Dermatol. Dec 2004; 51(6):923-30. Goldgeier M, Alessi-Fox C, Zavislan JM, Harris D, González S. "Noninvasive Imaging, Treatment and Microscopic Confirmation of Clearance of Basal Cell Carcinoma". Dermatol Surg. Mar 2003; 29(3):205-10. González S, Tannous Z. "Real-time, In Vivo Confocal Reflectance Microscopy of Basal Cell Carcinoma". J Am Acad Dermatol. Dec 2002; 47(6):869-74. Sauermann K, Gambichler T, Wilmert M, Rotterdam S, Strucker M, Altmeyer P, Hoffman K. "Investigation of basal Cell Carcinoma by Confocal Laser Scanning Microscopy In Vivo". Skin Res Technol. Aug 2002; 8(3):141-7. Abramovits W, Goldstein AM, González S. "Confocal Microscopy Oriented Cryosurgery". Int J Dermatol. May 2002; 41(5):284-5. Squamous Cell Carcinoma and Actinic KeratosisAghassi D, Anderson RR, González S. "Confocal Laser Microscopic Imaging of Actinic Keratosis In Vivo: A Preliminary Report". J Am Acad Dermatol. July 2000; 43(1 Pt 1):42-8. González S, White WM, Rubinstein G, Rajadhyaksha M, Zavislan J, Fewkes JL, Anderson RR. "In Vivo Real-Time Confocal Imaging of Non-Pigmented Cutaneous Neoplasms". J Invest Dermatol. Apr 1998; 110(4):583. Ulrich, M, Maltausch, A, Rower-Huber, J, Gonzalez, S, Sterry W, Stockfleth, E, Astner, S. "Actinic Keratoses: non-invasive diagnosis for field cancerisation". British Journal of Dermatology. 2007; 156 (Suppl.3), 13-17. Mohs SurgeryChung VQ, Dwyer P, Nehal KS, Rajadhyaksha M, Menaker GM, Charles C, Jiang SB. "Use of ExVivo Confocal Scanning Laser Microscopy during Mohs Surgery for Nonmelanoma Skin Cancers". Dermatol Surg. Dec 2004; 30(12 Pt 1):1470-8. Torres A, Niemeyer A, Berkes B, Marra D, Schanbacher C, González S, Owens M, Morgan B. "5% Imiquimod Cream and Reflectance-Mode Confocal Microscopy as Adjunct Modalities to Mohs Micrographic Surgery for Treatment of Basal Cell Carcinoma". Dermatol Surg. Dec 2004; 30(12 Pt 1):1462-9. Tannous Z, Torres A, González S. "In Vivo Real-Time Confocal Reflectance Microscopy: a Noninvasive Guide for Mohs Micrographic Surgery Facilitated by Aluminum Chloride, an Excellent Contrast Enhancer". Dermatol Surg. Aug 2003; 29(8):839-46. Torres, A. "Confocal Microscopy Sees Tumor Margins Well". e Skin & Allergy News.Feb 2003; 34(2). (NR) Tannous Z. "In Vivo Microscope brings Speed, Convenience to Mohs Surgery".e Skin & Allergy News. Sept 2002; 33(9). (NR) Rajadhyaksha M, Menaker G, González S, Zavislan J, Dwyer P. "Confocal Cross-Polarized Imaging of Skin Cancers to Potentially Guide Mohs Micrographic Surgery". Optics & Photonics News. Dec 2001. (NR) Rajadhyaksha M, Menaker G, Flotte TJ, Dwyer P, González S. "Confocal Examination of Non- Melanoma Cancers in Thick Skin Excisions to Potentially Guide Mohs Micrographic Surgery without Frozen Histopathology". J Invest Dermatol. Nov 2001; 117(5):1137-43. SchneiderI. "Laser Microscopy Enhances Mohs Surgery for Skin Cancer". Laser Focus World. Medical Laser Report. June 2001; 15(6). (NR) Rajadhyaksha M, Menaker G, González S. "Confocal Microscopy of Excised Human Skin Using Acetic Acid and Crossed Polarization: Rapid Detection of Non-Melanoma Skin Cancers". SPIE Proceedings. 2000; 3907:84-88. (NR) Other Skin Disease AND SKIN IMAGING ApplicationsO'goshi K, Suihko C, Serup J. "In Vivo Imaging of Intraepidermal Tattoos by Confocal Scanning Laser Microscopy". Skin Res Technol. May 2006; 12(2):94-8. Longo C, Bassoli S, Monari P, Seidenari S, Pellacani G. "Reflectance-Mode Confocal Microscopy for the In Vivo Detection of Sarcoptes Scabiei". Arch Dermatol. Oct 2005; 141(10):1336. Herndon TO, González S, Gowrishankar TR, Anderson RR, Weaver JC. "Transdermal Microconduits by Microscission for Drug Delivery and Sample Acquisition". BMC Med. Apr 19, 2004; 2:12. Sauermann K, Gambichler T, Jaspers S, Radenhausen M, Rapp S, Reich S, Altmeyer P, Clemann S, Teichmann S, Ennen J, Hoffmann K. "Histometric Data Obtained by In Vivo Confocal Laser Scanning Microscopy In Patients With Systemic Sclerosis". BMC Dermatol. Aug 6, 2002; 2:8. Gambichler T, Rapp S, Sauermann K, Jansen T, Hoffmann K, Altmeyer P. "Uncommon Vascular Naevi Associated With Focal Acantholytic Dyskeratosis". Clin Exp Dermatol. May 2002; 27(3):195-8. Goldgeier M, Alessi Fox C, Muhlbauer JE. "Immediate Noninvasive Diagnosis of Herpesvirus by Confocal Scanning Laser Microscopy". J Am Acad Dermatol. May 2002; 46(5):783-5. Kreuter A, Gambichler T, Sauermann K, Jansen T, Altmeyer P, Hoffmann K. "Extragenital Lichen Sclerosis Successfully Treated With Topical Calcipotriol: Evaluation By In Vivo Confocal Laser Scanning Microscopy". Br J Dermatol. Feb 2002; 146(2):332-3. Tachihara R, Choi C, Langley RG, Anderson RR, González S. "In Vivo Confocal Imaging of Pigmented Eccrine Poroma". Dermatology. 2002; 204(3):185-9. González S, Sackstein R, Rajadhyaksha M, Anderson RR. "Real-Time Evidence of In Vivo Leukocyte Trafficking in Human Skin by Reflectance Confocal Microscopy". J Invest Dermatol. Aug 2001; 117(2):384-6. Markus R, Huzaira M, Anderson RR, González S. "A Better Potassium Hydroxide Preparation? In Vivo Diagnosis of Tinea with Confocal Microscopy". Arch Dermatol. Aug 2001; 137(8):1076-8. Aghassi D, Anderson RR, González S. "Time-Sequence Histologic Imaging of Laser-Treated Cherry Angiomas with In Vivo Confocal Microscopy". J Am Acad Dermatol. Jul 2000; 43(1 Pt 1):37-41. Aghassi D, González E, Anderson RR, Rajadhyaksha M, González S. "Elucidating the Pulsed Dye Laser Treatment of Sebaceous Hyperplasia In Vivo Using Real-Time Confocal Scanning Laser Microscopy". J Am Acad Dermatol. Jul 2000; 43(1 Pt 1):49-53. Hongcharu W, Dwyer P, González S, Anderson RR. "Confirmation of Onychomycosis by Confocal Microscopy". J Am Acad Dermatol. Feb 2000; 42(2 Pt 1):214-6. González S, Rubinstein G, Mordovtseva V, Rajadhyaksha M, Anderson RR. "In Vivo Abnormal Keratinization in Darier-White's Disease as Viewed by Real-Time Confocal Imaging". J Cutan Pathol. Nov 1999; 26(10):504-8. González S, Rajadhyaksha M, González-Serva A, White WM, Anderson RR. "Confocal Reflectance Imaging of Folliculitis In Vivo: Correlation with Routine Histology". J Cutan Pathol. Apr 1999; 26(4):201-5. González S, White WM, Rajadhyaksha M, Anderson RR, González E. "Confocal Imaging of Sebaceous Gland Hyperplasia In Vivo to Assess Efficacy and Mechanism of Pulsed Dye Laser Treatment". Lasers Surg Med. 1999; 25(1):8-12. González S. "Characterization of Psoriasis In Vivo by Confocal Reflectance Microscopy". J Med. 1999; 30(5-6):337-356. González S, Rajadhyaksha M, Anderson RR. "non-invasive (Real-Time) Imaging of Histologic Margin of a Proliferative Skin Lesion In Vivo". J Invest Dermatol. Sept 1998; 111(3):538-9. Personal Care Product ApplicationsAllergic and Irritant Contact DermatitisAstner S, Burnett N, Rius-Díaz F, Doukas AG, González S, Gonzalez E. "Irritant Contact Dermatitis Induced by a Common Household Irritant: A Noninvasive Evaluation of Ethnic Variability in Skin Response". J Am Acad Dermatol. Mar 2006; 54(3):458-65. Astner S, Gonzalez E, Cheung A, Rius-Diaz F, González S. "Pilot Study on the Sensitivity and Specificity of In Vivo Reflectance Confocal Microscopy in the Diagnosis of Allergic Contact Dermatitis". J Am Acad Dermatol. Dec 2005; 53(6):986-92. Astner S, González E, Cheung A, Rius-Díaz F, Doukas A, William F, González S. "non-invasive Evaluation of the Kinetics of Allergic and Irritant Contact Dermatitis". J Invest Dermatol. Feb 2005; 124(2):351-9. Swindells K, Burnett N, Rius-Diaz F, González E, Mihm M, González S. "Reflectance Confocal Microscopy may Differentiate Acute Allergic and Irritant Contact Dermatitis In Vivo". J Am Acad Dermatol. Feb 2004; 50(2):220-8. Hicks S, Swindells K, Middelkamp-Hup M, Sifakis M, González E, González S. "Confocal Histopathology of Irritant Contact Dermatitis In Vivo and the Impact of Skin Color (Black vs White)". J Am Acad Dermatol. May 2003; 48(5):727-34. Burnett, N. "Confocal Microscopy Helps Distinguish between Allergic and Irritant Contact Dermatitis". e Skin & Allergy News. Feb 2003; 34(2). (NR) González S, González E, White WM, Rajadhyaksha M, Anderson, RR. "Allergic Contact Dermatitis: Correlation of In Vivo Confocal Imaging to Routine Histology". J Am Acad Dermatol. May 1999; 40(5 Pt 1):708-13. Photodamage and AgingGambichler T, Hyun J, Tomi NS, Moussa G, Moll C, Sommer A, Altmeyer P, Hoffmann K. "A Comparative Pilot Study on Ultraviolet-induced Skin Changes Assessed by non-invasive Imaging Techniques In Vivo". Photochem Photobiol. Jul 2006; 82:1103-07. Sauermann K, Jaspers S, Koop U, Wenck H. "Topically Applied Vitamin C Increases the Density of Dermal Papillae in Aged Human Skin". BMC Dermatol. Sep 29, 2004; 4(1):13. Gambichler T, Sauermann K, Altintas MA, Altmeyer P, Hoffmann K. "Acute Effect of Solar- Simulated Radiation on Epidermal Thickness Assessed by Confocal Laser Scanning Microscopy In Vivo". J Eur Acad Dermatol Venereol. Sep 2004; 18(5):638-9. Gambichler T, Sauermann K, Altintas MA, Paech V, Kreuter A, Altmeyer P, Hoffman K. "Effects of Repeated Sunbed Exposures on the Human Skin. In Vivo Measurements with Confocal Microscopy". Photodermatol Photoimmunol Photomed. Feb 2004; 20(1):27-32. Sauermann K, Clemann S, Jaspers S, Gambichler T, Altmeyer P, Hoffmann K, Ennen J. "Age Related Changes of Human Skin Investigated with Histometric Measurements by Confocal Laser Scanning Microscopy In Vivo". Skin Res Technol. Feb 2002; 8(1):52-6. PigmentationYamashita T, Negishi K, Hariya T, Kunizawa N, Ikuta K, Yanai M, Wakamatsu S. "Intense Pulsed Light Therapy for Superficial Pigmented Lesions Evaluated by Reflectance-Mode Confocal Microscopy and Optical Coherence Tomography". J Invest Dermatol. Oct 2006; 126(10):2281-6. Taylor S, Westerhof W, Im S, Lim J. "Noninvasive Techniques for the Evaluation of Skin Color". J Am Acad Dermatol. May 2006; 54(5 Suppl 2):S282-90. Middelkamp-Hup MA, Park H-Y, Lee J, Gilchrest BA, González S. "Detection of UV-Induced Pigmentary and Epidermal Changes Over Time Using In Vivo Reflectance Confocal Microscopy". J Invest Dermatol. Feb 2006; 126(2):402-7. Yamashita T, Kuwahara T, González S, Takahashi M. "non-invasive Visualization of Melanin and Melanocytes by Reflectance-Mode Confocal Microscopy". J Invest Dermatol. Jan 2005; 124(1):235-40. Park H-Y, Lee J, González S, Middlekamp-Hup MA, Kapasi, S, Peterson S, Gilchrest BA "Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation". J Invest Dermatol. Jan 2004; 122:159-66. Rajadhyaksha M, Grossman M, Esterowitz D, Webb RH, Anderson RR. "In Vivo Confocal Scanning Laser Microscopy of Human Skin: Melanin Provides Strong Contrast". J Invest Dermatol. Jun 1995; 104(6):946-52. Confocal Imaging of HairFox CA, Koon DC, Eastman JM. "Confocal Imaging of Human Hair for Cosmetic Applications". Poster Presentation. TRI Princeton Hair Research Conference. Jun 2004. (NR) Hadjur C, Daty G, Madry G, Corcuff P. "Cosmetic Assessment of the Human Hair by Confocal Microscopy". Scanning. Mar-Apr 2002; 24(2):59. (This publication does not reference the VivaScope® but the VivaScope® can be used for similar studies.) Quantitative Skin MeasurementsNouveau-Richard S, Monot M, Bastien P, de Lacharriére O. "In Vivo Epidermal Thickness Measurement: Ultrasound vs. Confocal Imaging". Skin Res Technol. May 2004; 10(2):136-40. Huzaira M, Rius F, Rajadhyaksha R, Anderson RR, González S. "Topographic Variations in Normal Skin, as Viewed by In Vivo Reflectance Confocal Microscopy". J Invest Dermatol. Jun 2001; 116(6):846-52. Kolbe L, Kligman AM, Schreiner V, Stoudemayer T. "Corticosteroid-Induced Atrophy and Barrier Impairment Measured by non-invasive Methods in Human Skin". Skin Res Technol. May 2001; 7(2):73-7. Sadiq I, Stoudemayer T, Kligman AM. "In Vivo Confocal Microscopy Can Be Used To Measure The Thickness of Human Horny Layer and its Response to Chemicals Which Cause Swelling".Poster presentation. American Academy of Dermatology Annual Meeting. Mar 2000. (NR) Rajadhyaksha M, González S, Zavislan JM, Anderson RR, Webb RH. "In Vivo Confocal Scanning Laser Microscopy of Human Skin II: Advances in Instrumentation and Comparison to Histology". J Invest Dermatol. Sep 1999; 113(3):293-303. Sadiq I, Pagnoni A, Kligman D, Stoudemayer T, Costa KA, Mills OH, Kligman, AM. "In Vivo Confocal Scanning Laser Microscopy of Skin". Poster presentation. AmericanAcademy of Dermatology Annual Meeting. Mar 1999. (NR) Confocal Imaging of Tissues other than SkinCampo-Ruiz V, Patel D, Anderson RR, Delgado-Baeza E, Gonzalez S. "Virtual Biopsy of the Joint Tissues using Near-Infrared, Reflectance Microscopy. A pilot study". Microsc Res Tech. Oct 2006; 69(10):794-8. Campo-Ruiz V, Lauwers GY, Anderson RR, Delgado-Baeza E, González S. "Novel Virtual Biopsy of the Kidney With Near Infrared, Reflectance Confocal Microscopy: A Pilot Study In Vivo and Ex Vivo". J Urol. Jan 2006; 175(1):327-36. Campo-Ruiz V, Patel D, Anderson RR, Delgado-Baeza E, González S. "Evaluation of Human Knee Meniscus Biopsies with Near-Infrared, Reflectance Confocal Microscopy. A Pilot Study". Int J Exp Pathol. Oct 2005; 86(5):297-307. Campo-Ruiz V, Lauwers GY, Anderson RR, Delgado-Baeza E, González S. "In Vivo and Ex Vivo Virtual Biopsy of the Liver with Near-Infrared, Reflectance Confocal Microscopy". Mod Pathol. Feb 2005; 18(2):290-300. White WM, Baldassano M, Rajadhyaksha M, González S, Tearney G, Anderson RR, Fabian RL. "Confocal Reflectance Imaging of Head and Neck Surgical Specimens: A Comparison to Histology". Arch Otolaryngol Head Neck Surg. Aug 2004; 130(8):923-8. Campo-Ruiz V, Ochoa ER, Lauwers GY, González S. " Evaluation of Hepatic Histology by Near- Infrared Confocal Microscopy: A Pilot Study". Hum Pathol. Oct 2002; 33(10):975-82. White WM, Tearney G, Pilch B, Fabian RL, Anderson RR, Gaz R. "A Novel, Noninvasive Technique for Intraoperative Assessment of Parathyroid Glands: Confocal Reflectance Microscopy". Surgery. Dec 2000; 128(6):1088-1101; discussion 1100-1. White WM, Rajadhyaksha M, González S, Fabian RL, Anderson RR. "Noninvasive Imaging of Human Oral Mucosa In Vivo by Confocal Reflectance Microscopy". Laryngoscope. Oct 1999; 109(10):1709-17. Small Animal ResearchLi Y, González S, Terwey TH, Wolchok J, Li Y, Aranda I, Toledo-Crow R, Halpern AC. "Dual Mode Reflectance and Fluorescence Confocal Laser Scanning Microscopy for In Vivo Imaging Melanoma Progression in Murine Skin". J Invest Dermatol. Oct 2005; 125(4):798-804. Kobayashi A, Yoshita T, Sugiyama, K. "White-Light and Laser Confocal Microscopic Findings of Rabbit Conjunctiva". Ophthalmic Surg Lasers Imaging. Mar-Apr 2004; 35(2):146-8. Kobayashi A, Yoshita T, Sugiyama K, Tseng S. "Detection of Rabbit Corneal Epithelium Over Amniotic Membrane Patch by White-light and Laser Confocal Microscopy". Am J Ophthalmol. Sept 2003; 136(3):569-72. Wang L, Demirs J, Pathak M, González S. "Real-Time In Vivo Quantification of Melanocytes by Near-Infrared Reflectance Confocal Microscopy in the Guinea Pig Animal Model". J Invest Dermatol. Aug 2002; 119(2): 533-5. Keck T, Campo-Ruiz V, Warshaw AL, Anderson RR, Fernández-del Castillo C, González S. "Evaluation of Morphology and Microcirculation of the Pancreas by Ex Vivo and In Vivo Reflectance Confocal Microscopy". Pancreatology. 2001; 1(1):48-57. Koenig F, González S, White WM, Lein M, Rajadhyaksha M. "Near-Infrared Confocal Laser Scanning Microscopy of Bladder Tissue In Vivo ". Urology. Apr 1999: 53(4):853-7. Related Research* The following publications may not reference the VivaScope®. Leeson DT, Meyers CL, Subramanyan K. "In Vivo Confocal Fluorescence Imaging of Skin Surface Cellular Morphology: A Pilot Study of its Potential as a Clinical Tool in Skin Research". Int J Cosmet Sci. 2006; 28:9-20. Naylor MF, Crowson N, Kuwahara R, Teague K, Garcia C, Mackinnis C, Haque R, Odom C, Jankey C, Cornelison RL. "Treatment of Lentigo Maligna with Topical Imiquimod". Br J Dermatol. Nov 2003; 149 Suppl 66:66-70. Wozniak K, Kazama T, Kowalewski C. "A Practical Technique for Differentiation of Subepidermal Bullous Disease". Arch Dermatol. Aug 2003; 139(8):1007-11. Smithpeter C, Dunn A, Welch A.J, Richards-Kortum R. "Penetration Depths Limits of In Vivo Confocal Reflectance Imaging". Appl Opt. May 1998; 37(13): 2749-54. Corcuff P, Gonnard G, Piérard, Lévêque J.L. "In Vivo Confocal Microscopy of Human Skin: A New Design for Cosmetology and Dermatology". Scanning. Aug 1996; 18(5):351-5. Warren R, Gartstein V, Klingman AM, Montagna W, Allendorf RA, Ridder GM. "Age, Sunlight, and Facial Skin: A Histologic and Quantitative Study". J Am Acad Dermatol. Nov 1991; 25(5 Pt 1):751-60. Reflectance Confocal Microscopy - TechnologyDwyer PJ, DiMarzio CA, Zavislan JM, Fox WJ, Rajadhyaksha M. "Confocal Reflectance Theta Line Scanning Microscope for Imaging Human Skin In Vivo". Opt Lett. Apr 1, 2006; 31(7):942-4. Yaroslavsky A, Barbosa J, Neel V, DiMarzio C, Anderson RR. "Combining Multispectral Polarized Light Imaging and Confocal Microscopy for Localization of Nonmelanoma Skin Cancer". J Biomed Opt. Jan-Feb 2005; 10(1):14011. Gruber M, Wackernagel A, Richting E, Koller S, Kerl H, Smolle J. "Digital Image Enhancement for In Vivo Laser Scanning Microscopy". Skin Res Technol. Nov 2005; 11(4):248-53. Caspers PJ, Lucassen GW, Puppels GJ. "Combined In Vivo Confocal Raman Spectroscopy and Confocal Microscopy of Human Skin". Biophys J. Jul 2003; 85(1):572-80. Dwyer PJ, DiMarzio CA, Rajadhyaksha M. "Confocal Reflectance Theta Line-Scanner for Imaging Human Skin In Vivo". Optical Society of America 2003. Wan DS, Rajadhyaksha M, Webb RH. "Analysis of Spherical Aberration of a Water Immersion Objective: Application to Specimens with Refractive Indices 1.33-1.40". J Microsc. Mar 2000; 197(Pt 3):274-84. Rajadhyaksha M, González S. "Confocal Microscopy of Human Tissues In Vivo". Optics & Photonics News. Dec 1999; 10-11. Webb RH, Rogomentich F. "Confocal Microscope with Large Field and Working Distance". Appl Opt. Aug 1999; 38:4870-5. Rajadhyaksha M, Anderson RR, Webb, RH. "Video-rate Confocal Scanning Laser Microscope for Imaging Human Tissues In Vivo". Appl Opt. Apr 1999; 38(10):2105-15. Webb RH. "Theoretical Basis of Confocal Microscopy". Methods Enzymol. 1999; 307:3-20. Rajadhyaksha M, Zavislan JM. "Confocal Reflectance Microscopy of Unstained Tissue In Vivo". Retinoids & Lipid-Soluble Vitamins in Clinical Practice. 1998; 14(1):26-30. Rajadhyaksha M. "Confocal Reflectance Microscopy: Diagnosis of Skin Cancer Without Biopsy? Frontiers of Engineering. 1998; 24-33. (NR) Rajadhyaksha M, Zavislan JM. "Confocal Laser Microscope Images Tissue In Vivo". Laser Focus World. Feb 1997. (NR) Other MaterialsGonzález S, Alessi C. "An Atlas of Confocal Images of Human Skin In Vivo Second Edition". 2005 Atlas provided on CD compliments of Lucid, Inc. (NR) Menaker GM, Dwyer PJ, Rajadhyaksha M, González S, Zavislan JM. "Confocal Microscopy for Mohs Surgery: An Atlas of Images". Atlas provided on CD, compliments of Lucid, Inc. (NR)
American Cancer Society. "Laser May Offer non-invasive Melanoma Diagnosis". Sep.
2001 http://www.cancer.org/docroot/NWS/content/ Itkin M, Goldgeier M, Zavislan J "Will the Laser Confocal Microscope (VivaScope®) Revolutionize Clinical Practice?" The Bulletin MonroeCounty Medical Society. Sep 2000; 2:31. (NR) 2006NOV10 |
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